Anti-Aging and Wrinkles: 2 Retinoids (Vitamin A Cousins)

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  • Zero Irritation Retinol
    Zero Irritation Retinol
    Madison MD

    Size: 1.7 fl oz

    Dr. Irwin's Product Review

     The key to the zero irritation is in the base cream and the way you use it.  The base is very hydrating and moisturizing with triglycerides, shea butter, and avocado oil.  This formula is focused to improve sun damage, wrinkles and help to prevent skin cancers (like all topical retinoids).  Also contains small amounts of vitamin E, Vit B5 (panthenol), and chamomile extract.

    Be sure to apply at night OVER your moisturizer after waiting about 5 minutes.

    Free of: Animal cruelty, parabens, propylene glycol, & fragrance

     KEY INGREDIENTS: Water/Aqua/Eau, Cyclopentasiloxane, Caprilyc/Capric Triglycerides, Butyrospermum Parkii (Shea Butter), Polysorbate 60, Persea Gratissima (Avocado) Oil, Dimethicone, Retinol, Tocopheryl Acetate, Panthenol, Glycerin, Polysorbate 20, Cucumis Sativus (Cucumber) Fruit Extract, Chamomilla Recutita (Matricaria) Flower Extract, Xan-than Gum, Allantoin, Ceramide NP, PEG-8, PEG-8/SMDI Copolymer,Palmitoyl Myristyl Serinate, Sodium Polyacrylate, Tetrasodium EDTA, Caprylyl Glycol, Ethylhexylglycerin, Methylisothiazolinone, Phenoxyethanol


  • Retinol for Wrinkles and Skin Care
    Retinol Complex .25

    Size: 1 oz

    Who It's For

    For sun-damaged skin and for those wanting to prevent the appearance of wrinkles and aging.

    Dr. Irwin's Product Review

     This is SkinMedica's updated version of the old Tri-Retinol Complex, and it is still an excellent over-the-counter retinol.  At this percentage, the effects are similar to Renova/tretinoin, etc. Use at night. If you can use the prescription version of tretinoin (like Renova), do so - but many people don’t want to be bothered with a prescription and the two retinols listed on this site are almost as good. This retinol also has vitamin E in a base that will not clog pores and is still compatible with moisturizers and sunscreens. Also see the Neocutis Nouvelle+Retinol Correction Cream.  Start with this one though if you have never used a retinoid before.

    Retinoids are repair creams that have 20 years of science and experience behind them. They build collagen and normalize sun damaged keratinocytes (skin cells) and help to prevent precancerous growths and skin cancers if used regularly. 

    How to Use

    Apply one pump to the face at night. Always use at night - light inactivates it. Begin using twice per week, then increase gradually.  If this product irritates your skin a little, try applying your moisturizer first, then wait 10-20 minutes, then apply this. You must use a sunscreen every morning if you use a retinoid because your skin will be just slightly more sun sensitive.  Stop this product a week before sunny vacations and consider not using it if you can't be consistent with sunscreen or truly are outdoors constantly. 


    Water/Aqua/Eau, Cetyl Ethylhexanoate, Glycine Soja (Soybean) Oil, Niacinamide, Polyacrylate-13, Squalane, Retinol, Palmitoyl Tripeptide-8, Dunaliella Salina Extract, Magnolia Grandiflora Bark Extract, Tocopherol, Tocotrienols, Ceramide 3, Bisabolol, Phytosterols, Squalene, Tocopheryl Acetate, Oryza Sativa (Rice) Bran Wax (Oryza Sativa Cera), Glycerin, Caprylic/Capric Triglyceride, Polysorbate 20, Butylene Glycol, Cetyl Palmitate, Laureth-23, Trideceth-6 Phosphate, Sodium Hydroxide, Dicaprylyl Ether, Lauryl Alcohol, Polyisobutene, Dextran, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin

  • Antiaging wrinkle cream with retinol
    Retinol 1.0

    Size: 1 fl. oz

    Who It's For

    Almost everyone who's trying to repair sun damage and prevent wrinkles and skin cancers should be on one of these vitamin A "cousins."   A few will be too sensitive for retinoids and should use a combination of cell growth factors and antioxidants instead.  Don't use if you have a propylene glycol allergy. 

    Dr. Irwin's Product Review

    This product is now an excellent value for its price point!   The generic prescription tretinoin and all the prescription retinoids like Renova have gotten very expensive.  This product is quite similar in strength to Retin A .25% but at a much better price.   If you've used prescription products before, you should do well with this.   If you haven't used them before, consider starting with the SkinMedica Retinol .25 first, then going to the NeoCutis Nouvelle+ (.6%), and then this SkinCeuticals 1.0.

    How to Use

    Always at night.  Usually best to put a moisturizer on, wait 5-10 minutes and then apply a pea sized amount.  You don't need very much. 


    Water, Cyclomethicone, Cyclopentasiloxane, Dimethicone Crosspolymer, Dimethicone, Dimethiconol, Laureth-4, Laureth-23, Hydrogenated Lecithin, Butyorspermum Parkii (shea Butter), Caprylic/capric Triglyceride, Ceramide 2, Ceramide 3, Phytosphingosine, Cholesterol, Hypericum Perforatum Extract, Propylene Glycol, Allyl Methacrylate Crosspolymer, Polysorbate 20, Retinol, BHT, Sodium Polyacrylate, Dimethicone PEG-7 Isostearate, Glycerin, Polyacrylamide, C13-14 Isoparaffin, Leureth-7, Bisabolol. Rosa Canina Leaf Extract, Silybum Marianum Fruit Extract, Passiflora Incarnata Flower Extract, Chamomilla Recutita (matreicaria) Leaf Extract, Citric Acid, Methylsothiazolinone, Tetrasodium EDTA

Dr. Brandith Irwin, MD

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Hi, I’m Dr. Irwin, and I believe that consumers need and deserve a medically trained and unbiased skincare advocate.

  • All our content is written and researched by myself and my trained staff.
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